Sadio Mane's red card left Liverpool vulnerable and Manchester City capitalised in a 5-0 win on Saturday.
Manchester City underlined their Premier League title credentials with a 5-0 thrashing of Liverpool as Sergio Aguero set a goalscoring landmark and Sadio Mane saw red.
Saturday's contest at the Etihad Stadium burst into life when Aguero broke the deadlock to become the Premier League's all-time leading non-European goalscorer on 124.
Liverpool were left facing a huge uphill battle when Mane was dismissed for raising his boot in a challenge for a bouncing ball with goalkeeper Ederson, who was taken off on a stretcher after prolonged treatment, but later confirmed to have escaped serious injury.
Gabriel Jesus' header doubled City's lead in the stoppage time that resulted from that delay and he scored again early in the second half to end any hopes Jurgen Klopp's side had of mounting a comeback.
Substitute Leroy Sane capped a brilliant team move and superb display from the hosts by netting an excellent brace, bringing to an end Klopp's impressive record against City, having enjoyed a return of 10 points from his previous four matches with them. Klopp also endured the joint-heaviest defeat of his managerial career.
The victory takes Pep Guardiola's men to the summit for at least a few hours, with their opponents now three points back following a first loss of the campaign.